|
| | Gene
Causes Cancer to Spread
Research
Could Lead to Better, Milder Cancer Treatments
March
5, 2003 -- A gene seems to trigger the lethal spread of cancer cells linked with
breast, uterine, ovarian, and prostate cancer, new research shows. This
discovery may make possible new, less toxic, more effective chemotherapies to
halt this spread.
"Slowing
down the disease may change cancer from a fatal disease to one that can be lived
with, like diabetes," says researcher Richard G. Pestell, MD, PhD, director
of the Lombardi Cancer Center at Georgetown University in Washington, in a news
release.
The
groundbreaking yet preliminary study appears in the May 2003 issue of the
journal Molecular Biology of the Cell.
"Patients
who do not survive their cancer often don't die from their primary cancer.
Usually they die from the spread of the disease through the body," Pestell
says.
"If
we can understand what causes the metastasis [the spread of cancer cells], then
we can pinpoint new targets to block the spread of disease," he says.
In studies involving mice, . They have found that by
switching off this gene, the migration of cancer cells can be halted.
Evidence
of excessive cyclin D1 has been found in breast, uterine, ovarian, and prostate
cancer.
Pestell
says he foresees a new form of chemotherapy that targets just this cell
migration. Only cancerous cells migrate, he says.
"Killing
only migrating cancer cells is thus less toxic, producing fewer side effects,
than current chemotherapy, which targets dividing cells of all types,"
Pestell explains. Many healthy dividing cells, such as in the stomach and hair,
are destroyed by chemotherapy.
 Aloha From Hawaii!
Prostate Cancer Diagnosis What You Should Know
Gene
Causes Cancer to Spread Research
Could Lead to Better, Milder Cancer Treatments,
breast, uterine, ovarian, and prostate cancer, new research shows, Slowing
down the disease may change cancer from a fatal disease to one that can be lived
with, like diabetes," says researcher Richard G. Pestell, MD, PhD, director
of the Lombardi Cancer Center at Georgetown University in Washington, Molecular Biology of the
Cell, causes the metastasis [the spread of cancer cells], Pestell team spent the past decade
studying cyclin D1 gene protein produces
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 Mahalo
(Thanks)!
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biomarker portends aggressiveness, Arul M.
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Prostate Cancer Diagnosis What You Should Know,
Gene
Causes Cancer to Spread Research
Could Lead to Better, Milder Cancer Treatments,
breast, uterine, ovarian, and prostate cancer, new research shows, Slowing
down the disease may change cancer from a fatal disease to one that can be lived
with, like diabetes," says researcher Richard G. Pestell, MD, PhD, director
of the Lombardi Cancer Center at Georgetown University in Washington, Molecular Biology of the
Cell, causes the metastasis [the spread of cancer cells], Pestell team spent the past decade
studying cyclin D1 gene protein produces
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