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Green
and Black Tea Polyphenols Consumption Results in
Slower Prostate Cancer Cell Growth
Source:
psa-rising.com/eatingwell/index.html
Green
tea is pleasant to drink but do its health benefits actually reach the parts of
our bodies we hope to protect?
In the
first known study of the absorption and anti-tumor effects of green and black
tea polyphenols in human tissue, researchers at the University of California at
Los Angeles were able to detect tea polyphenols in prostate tissue after a very
limited consumption of tea.
reported by J. Strax
PSA Rising, New
York. April 23, 2004— In the first known study of the absorption and
anti-tumor effects of green and black tea polyphenols in human tissue,
researchers at the University of California at Los Angeles were able to detect
tea polyphenols in prostate tissue after a very limited consumption of tea.
More importantly,
the scientists found that prostate cancer cells grew more slowly when placed in
a medium containing blood serum of men who had consumed either green or black
tea for five days compared to serum collected before the men began their
tea-drinking regimen. Serum from men who drank comparable amounts of diet or
regular soda showed no such slowing in cancer cell proliferation.
The study was
reported at Experimental Biology 2004, in Washington, D.C., as part of the
scientific program of the American Society of Nutritional Sciences, one of the
six sponsoring scientific societies of this large multi-disciplinary meeting.
Recent animal and
epidemiological studies have suggested tea may have anti-tumor effects against
carcinoma of the prostate, and many of the polyphenolic components of tea have
been found in the prostate and many other tissues in rats and mice after chronic
consumption of green tea polyphenols in drinking water.
Dr. Susanne Henning,
UCLA Center for Human Nutrition, says the UCLA research team - a combination of
nutrition scientists and urologists - focused on the possible effect of tea
polyphenols on factors named polyamines and the enzymes responsible for the
production of polyamines. Elevated levels of polyamines have been associated
with malignancy in humans, including prostate cancer, and - since polyamines are
present in prostate tissue in high concentration - are considered a logical
target for chemoprevention of prostate cancer.
Five days before
they were to undergo radical prostatectomy, 20 men with prostate cancer were
randomly assigned to consume daily either five cups of green tea, five cups of
black tea, or diet or regular soda containing no tea polyphenols. Their blood
serum was then collected and added to prostate tissue samples from a
commercially available prostate cancer cell line called LNCaP.
Analysis of the
prostate tissue showed a large variation in tea polyphenol content between study
participants. Tea polyphenols were found in six out of eight participants
drinking green tea, seven out of seven drinking black tea, and two out of five
drinking soda. The fact that two of the control participants showed polyphenols
in the prostate sample might be because they were eating chocolate regularly or
drinking tea before entering the study. Chocolate does contain the polyphenols
epicatechin and epicatechingallate, and the turnover rate of these polyphenols -
how long they might remain in tissue - is not known. They are water-soluble and
are all excreted after eight hours. The maximum concentration in plasma is after
two to three hours.
But two important
factors were different in the men who drank tea and those who did not during the
five-day study.
When the scientists
compared the level of total polyamine to the total polyphenol content, the tea
drinkers showed a significant negative correlation - the more tea components in
the tissue, the less of the polyamines associated with malignancy.
And when the
scientists measured the proliferation of prostate cancer cells, there was a
significant decrease in how fast new cancer cells appeared for the men who had
consumed either green or black tea. That was true even when no tea components
could be detected in the serum, indicating, says Dr. Henning, that the
inhibition of cell proliferation was caused by other compounds altered through
tea consumption.
Prostate cancer is
one of the common cancers among males in the United States, and more than a
fourth of all those patients with prostate cancer are known to use alternative
therapies, including green tea. This study suggests that both black and green
tea are promising natural dietary supplements useful for chemoprevention of
prostate cancer, according to Dr. Henning. She plans to investigate if this
effect can be enhanced by consuming larger amounts of tea polyphenols in the
form of green tea extract supplement capsules.
Dr. Henning's
co-authors are Yantao Niu, Nicolas H. Lee, Francisco Conde, Pakshan Leun, Jenny
Hong, George Csathy, Hossein Ziaee, Vay L. W. Go, David Heber, and William J.
Aronson, of UCLA's Center for Human Nutrition, Department of Urology, and
Department of Physiology.
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"Tea can
fight against emerging cancer cells"
"American
scientists have found that drinking five small cups of tea a day can help to
boost the immune system and possibly fight against emerging cancer cells. The
alkylamine antigens present in tea, are also found in some bacteria, parasites,
tumor cells and fungi. When the human immune system has previously been exposed
to the antigen (by drinking tea), a much greater defense response is initiated
against the bacteria, parasite, tumor or fungi."
Health
& Hygiene, Summer 2003
"Tea is one
of the single best cancer fighters you can put in your body."
"Tea is
one of the single best cancer fighters you can put in your body," according
to Mitchell Gaynor, MD, director of medical oncology at the. world-renowned
Strong Cancer Prevention Center in New York City and co-author of Dr. Gaynor's
Cancer Prevention Program (Kensington Books, 1999.
The latest tea discovery? Strong evidence that both green and black tea can
fight cancer-at least in the test tube-though green tea holds a slight edge. In
a new study, both teas kept healthy cells from turning malignant after exposure
to cancer-causing compounds.
Prevention,
May 2000
"People who
drink about 4 cups of green tea a day seem to get less cancer. Now we may
know why."
In recent
test-tube studies, a compound called EGCG, a powerful antioxidant in tea,
inhibited an enzyme that cancer cells need in order to grow. The cancer cells
that couldn't grow big enough to divide self-destructed. It would take
about 4 cups of green tea a day to get the blood levels of EGCG that inhibited
cancer in the study. Black tea also contains EGCG, but at much lower
concentrations.
Prevention,
Aug 99
Green tea helps
bolster the body's defenses."
"Drinking
two or three American-size cups a day of green tea helps bolster the body's
defenses, especially as you age, suggests Lester A. Mitscher, PhD, professor of
medicinal chemistry at the University of Kansas in Lawrence and author of The
Green Tea Book: China's Fountain of Youth"
Prevention,
April 2003
"Green
tea extract may prevent breast cancer cells from manufacturing the new blood
vessels necessary to promote cancer cell growth"
Writing in a
recent issue of the International Journal of Cancer, the USC researchers noted
that the reduction in breast cancer risk among the green tea drinkers held true
even among women who had a family history of breast cancer as well as among
women who smoked or ate processed foods. Exercise habits - either good or bad -
also did not play a role in the outcome for green tea drinkers.
The conclusions of this study support the important results of a 2002 laboratory
study. According to a report in Science News, researchers at the University of
California and the University of Texas found that green tea extract may prevent
breast cancer cells from manufacturing the new blood vessels necessary to
promote cancer cell growth. If further research confirms these findings, it may
help explain why the green tea drinkers in the USC study were at lower risk of
breast cancer, regardless of other health, diet, and family history factors.
Department
of Preventive Medicine at USC, October 2003
 Aloha From Hawaii!
Black
Tea and Green Tea Can Be Healthy and Fight Prostate Cancer
No Risk Teapot &
Teas Offer
 Mahalo
(Thanks)!
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